ʻO Cycobalamin kekahi o nā huaʻai B complexes, nona ka hopena anti-pernicious anemia ikaika. ʻO ia ka inoa i hāʻawi ʻia e ka crystallization o ka huaora B12, kahi mea koʻikoʻi no ka hoʻomohala ʻana i nā maʻi bacteria a me nā holoholona. Ma waho aʻe o C, H, O, N, P a me Co, ʻo ka conjugate aD-ribose o 5,6-dimethe-rbenzimidazole kekahi ʻāpana o kona ʻano. AR Todd et al. e hoʻopuka i ke kumu hoʻolālā, i kapa ʻia ʻo cyanocobalamin no ka mea ua hoʻonohonoho ʻia ka cyano ma luna o ka cobalt. ʻO 278,361,548 nm ka nui loa o ka absorption i loko o ka solution aqueous. I ka makahiki 1948, ua unuhi kūʻokoʻa ʻo E．L．Rickes o ʻAmelika Hui Pū ʻIa a me E．L．Smith o United Kingdom i nā kristal mai ke ake. Mai ia manawa mai, ua loaa mai keia mea mai kekahi actinomycete (StrePtomyces griseum). ʻO Cyanocobalamin ka mea ulu o nā puaʻa a me nā moa, a ʻo ia ka mea like me ka mea protein holoholona e pono ai no ka hāʻule ʻana o nā hua manu. ʻO ka Vitamin B12, hāʻawi ʻia i nā poʻe maʻi me nā maʻi maʻi ma 150 micrograms, hiki ke hoʻonui i ke koko ʻulaʻula ma kahi o 2 mau manawa, a hiki i ka 3-6 micrograms ke hana i nā hopena. I loko o vivo, lawe ʻia i loko o ke koko ma ke ʻano o ka hui pū ʻana me ka protein trans-cobalamin (a- globular protein), a aia ma ke ʻano o ka coenzyme i loko o nā ʻiʻo like ʻole. Me ka folic acid, pili ia i ka metabolism o ka methyl transfer a me ka hana methyl hana. A lilo i kumu nui o purine, pyrimidine a me nā biosynthesis ʻē aʻe.
